Gender Features of Myocardial Revascularization Results in Patients with Stable Coronary Artery Disease, Multivascular Coronary Injury and Reduced Left Ventricular Systolic Function

Keywords: coronary heart disease, multivascular coronary artery disease, decreased left ventricular systolic function, coronary artery bypass grafting, percutaneous coronary intervention

Abstract

The aim. To investigate the course, quality of life and risk factors depending on gender in patients with stable isch-emic coronary disease, multivascular coronary injury and reduced left ventricular systolic function

Materials and methods. In a one-center study of the Ukrainian Children’s Cardiac Center, Clinic for Adults analyzed data from 107 patients with coronary artery disease, multivascular coronary artery injury and reduced left ventricular systolic function (LV EF below 35%), who underwent complete revascularization from January until December 2020. Among those surveyed were 67 (62.6%) men and 40 (37.4%) women aged 54 to 83 years. Myocardial infarction was diagnosed in 95 (88.7%) patients. Hypertension was diagnosed in 50 (74.6%) men and 35 (87.5%) women. Diabetes was registered in 13 (19.4%) men and 14 (35.0%) women.

Results and discussion. According to the multivariate analysis, the most significant factors in reaching the endpoint during the annual follow-up after CABG and PCI were: worse left ventricular systolic function; the presence of diabetes mellitus; and lack of postoperative statin therapy.

Conclusion. Gender features in long-term results after myocardial revascularization were revealed. Women were more likely to complain of angina in the postoperative period and rather hospitalized than men, but they were less likely to undergo myocardial revascularization. The quality of life after CABG and PCI in female patients was slightly reduced compared to that in men. After the intervention, men were less likely to take statins than women. Regardless of the type of myocardial revascularization in women, LV EF was higher than in men.

References

  1. Blankstein R, Ward RP, Arnsdorf M, Jones B, Lou YB, Pine M. Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery: contemporary analysis of 31 Midwestern hospitals. Circulation. 2005;112(9 suppl):I323-I327. https://doi.org/10.1161/CIRCULATIONAHA.104.525139
  2. Piña IL, Zheng Q, She L, Szwed H, Lang IM, Farsky PS, et al. Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization: Results From the STICH Trial (Surgical Treatment for Ischemic Heart Failure). Circulation. 2018 Feb 20;137(8):771-780. https://doi.org/10.1161/CIRCULATIONAHA.117.030526
  3. riskcalc.sts.org [Internet]. Society of Thoracic Surgeons. [cited 2018.11.15]. Available from: http://riskcalc.sts.org/stswebriskcalc/#/
  4. United Nations [Internet]. World population pros-pects 2019: highlights. [place unknown]: The Unit-ed Nations; [cited 2019.06.17]. Available from: https://population.un.org/wpp/Publications/Files/WPP2019_10KeyFindings.pdf
  5. Sampasa-Kanyinga H, Lewis RF. Frequent use of social networking sites is associated with poor psychological functioning among children and adolescents. Cyberpsychol Behav Soc Netw. 2015 Jul;18(7):380-5. https://doi.org/10.1089/cyber.2015.0055
  6. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2016 update: A report from the American Heart Association. Circulation. 2016 Apr 12;133(15):e184-е204. https://doi.org/10.1161/CIR.0000000000000409.
  7. 2018 ESC/EACTS Guidelines on myocardial revasculari-zation. Eur Heart J. 2019 Oct 1;40(37):3096. https://doi.org/10.1093/eurheartj/ehz507. Corrected and repub-lished from: Eur Heart J. 2019 Jan 7;40(2):87-165.
  8. Velazquez EJ, Lee KL, Deja MA, Jain A, Sopko G, Marchenko A, et al. Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction. The New England Journal of Medicine. 2011 Apr 28;364(17):1607-16. https://doi.org/10.1056/NEJMoa1100356
  9. Park SJ, Ahn JM, Kim YH, Park DW, Yun SC, Lee JY, et al. Trial of Everolimus-Eluting Stents or Bypass Surgery for Coronary Disease. N Engl J Med. 2015 Mar 26;372(13):1204-12. https://doi.org/10.1056/NEJMoa1415447
Published
2021-03-16
How to Cite
Kucheriava, M. V., Mankovskiy, G. B., & Rudenko, N. M. (2021). Gender Features of Myocardial Revascularization Results in Patients with Stable Coronary Artery Disease, Multivascular Coronary Injury and Reduced Left Ventricular Systolic Function. Ukrainian Journal of Cardiovascular Surgery, (1 (42), 38-43. https://doi.org/10.30702/ujcvs/21.4203/k011038-043/13-089