Effect of cord blood mononuclear stem cells transplantation on the improvement restoration of decreased myocardial contractility
Abstract
The existing methods of treating heart failure (HF) do not completely solve the problem, so the world is searching for alternative approaches. One of the newest methods is cell therapy. A number of studies have demonstrated the perceptivity of using mononuclear cord blood stem cells (MCB SC). However, the effect of MCB SC on myocardial contractility remains poorly studied.
Aim of study. To analyze the changes in contractility of the myocardium and parameters of intracardiac hemodynamics in patients with heart failure after transplantation of mononuclear stem cells of umbilical cord blood.
Materials and methods. We have analyzed the results of treatment of 20 patients with refractory HF, who underwent MCB SC transplantation in the schedule of conservative treatment.
Discussion. In the post-transplant period, a statistically significant increase in the left ventricular ejection fraction was registered, mainly due to a decrease in the end systolic index, as well as an improvement in the values of the local contractility index at the follow-up period up to 9 months.
Conclusions. The use of the cellular preparation “Cryopreserved human umbilical cord blood” in the schedule of con-servative treatment of the refractory HF made it possible to partially restore the reduced contractile function of the myocar-dium and to increase the effectiveness of traditional schemes of conservative treatment of HF in terms of up to 9 months.
References
2. Ефекти стовбурових клітин пуповинної крові при експериментальному ушкодженні міокарда / Поляченко Ю. В., Габрієлян А. В., Доманський Т. М. та ін. // Клінічна хірургія. – 2013. – № 7. – С. 56–60.
3. The global burden of cardiovascular disease / Deaton C., Froelicher E. S., Wu L. H. et al. // Eur J Cardiovasc Nurs. – 2011. – Vol. 10, Suppl 2. – P. 5–13.
4. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990– 2013: a systematic analysis for the Global Burden of Disease Study // Lancet. – 2015. – Vol. 385 (9963). – P. 117–171.
5. Long-term trends infirst hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people / Jhund P. S., Macintyre K., Simpson C. R. et al. // Circulation. – 2009. – Vol. 119. – P. 515–523.
6. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging / Lang R. M., Badano L. P., Mor-Avi V. et al. // Journal of the American Society of Echocardiography. – 2015. – Vol. 28 (1). – P. 1–39.
7. Human umbilical cord blood-derived CD133+ cells enhance function and repair of the infarcted myocardium / Leor J., Guetta E., Feinberg M. S. et al. // Stem Cells. – 2006. – Vol. 24. – P. 772–780.
8. Cord blood transplantation and stem cell regenerative potential / Liao Y., Geyer M. B., Yang A. J. et al. // Exp Hematol. – 2011. – Vol. 39. – P. 393–412.
9. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association (HFA)of the ESC / McMurray J. J. V., Adamopoulos S., Anker S. et al. // European Heart Journal. – 2012. – Vol. 33. – P. 1787–1847.
10. Mosterd A., Hoes A. W. Clinical epidemiology of heart failure // Heart. – 2007. – Vol. 93. – P. 1137–1146.
11. Roger V. L., Go A. S., Lloyd-Jones D. M. Heart Disease and Stroke Statistics–2011 Update A Report From the American Heart Association // Circulation. – 2011. – Vol. 123 (4). – P. 18–209.
12. The role and potential of umbilical cord blood in an era of new therapies: a review / Roura S., Pujal J. M., Gбlvez-Montуn C. // Stem Cell Res Ther. – 2015. – Vol. 6 (1). – P. 123.
13. Thirty-Year Trends in Mortality from Cardiovascular Diseases in Korea / Seung W. L., Kim H. C., Lee H. S. et al. // Korean Circ J. – 2015. – Vol. 45 (3). – P. 202–209.
14. Population impact of heart failure and the most common forms of cancer: a study of 1 162 309 hospital cases in Sweden (1988 to 2004) / Stewart S., Ekman I., Ekman T. et al. // Circ Cardiovasc Qual Outcomes. – 2010. – Vol. 3. – P. 573–580.
