The role of endothelial dysfunction in the formation of complications during interventional procedures

  • E. V. Aksenov National M. M. Amosov Institute of Cardiovascular Surgery National Academy of Medical Sciences of Ukraine
  • V. B. Golovenko National M. M. Amosov Institute of Cardiovascular Surgery National Academy of Medical Sciences of Ukraine
Keywords: coronary heart disease, interventional procedures complication, endothelial dysfunction

Abstract

The work deals with the role of endothelial dysfunction in the formation of complications during interventional procedures.

From the entire data (1680 patients with coronary heart disease), were selected 156 patients – 71 patients with different complications during diagnostic and therapeutic interventional coronary procedures and 85 consecutive patients who had no registered complications. Age of surveyed was 66,96±1,81 years. Among them – 104 men and 52 women.

In addition to routine clinical indicators of registration of patients, the target examination included determination of endothelial function (nitrate levels in plasma and red blood cells, the L-arginine, the number of desquamated endothelial (DE) in the blood plasma).

During the work has identified a strong positive correlation between the type of percutaneous coronary intervention and the degree of change in the level of DE, which was most expressed during percutaneous transluminal coronary angioplasty.

Manifestation of indicators of endothelial dysfunction in the form of increased levels of ED was more pronounced in patients with unstable angina form.

References

1. Endothelium-dependent vasomotor dysfunction in pig coronary arteries with Paclitaxel-eluting stents is associated with inflammation and oxidative stress / L.K. Pendyala, J. Li, T. Shinke, [et al.] // JACC Cardiovasc. Interv. – 2009. –Vol. 2, № 3. – Р. 253–262.

2. Endothelial dysfunction following drug-eluting stent implantation: a systematic review of the literature / Y. Minami, H. Kaneda, M. Inoue, [et al.] // Int. J. Cardiol. –2013. – Vol. 165, № 2. – Р. 222–228.

3. Hamasaki S. Effect of coronary endothelial function on outcomes in patients undergoing percutaneous coronary intervention / S. Hamasaki, C. Tei // J. Cardiol. – 2011. –Vol. 57, № 3. – Р. 231–238.

4. Outcomes of percutaneous coronary intervention in intermediate coronary artery disease: fractional flow reserve-guided versus intravascular ultrasound-guided / C. W. Nam, H. J. Yoon, Y. K. Cho, [et al] // JACC Cardiovasc, Interv. – 2010. – Vol. 3, № 8. – Р. 812–817.

5. Outcomes with various drug-eluting or bare metal stents in patients with ST-segment-elevation myocardial infarction: a mixed treatment comparison analysis of trial level data from 34 068 patient-years of follow-up from randomized trials // S. Bangalore, N. Amoroso, M. Fusaro, [et al] // Circ. Cardiovasc. Interv. – 2013. – Vol. 6, № 4. – Р. 378–390.

6. The effects of stenting on shear stress: relevance to endothelial injury and repair / K. Van der Heiden, F. J. Gijsen, A. Narracott, [et al.] // Cardiovasc. Res. – 2013. –Vol. 99, № 2. – Р. 269–275.

7. The long-term effect of coronary stenting on epicardial and microvascular endothelial function / S.H. Lim, A. J. Flammer, M. H. Yoon [et al.] // Circ. Cardiovasc. Interv. – 2012. – Vol. 5, № 4. – Р. 523–529.

8. Time course of endothelium-dependent and -independent coronary vasomotor response to coronary balloons and stents. Comparison of plain and drug-eluting balloons and stents / C. A. Plass, I. Sabdyusheva-Litschauer, A. Bernhart, [et al.] // JACC Cardiovasc. Interv. – 2012. –Vol. 5, № 7. – Р. 741–751.

9. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions / G. N. Levine, E. R. Bates, J. C. Blankenship, [et al] // Catheter. Cardiovasc. Interv. – 2012. – Vol. 79, № 3. – Р. 453–495.
Published
2016-09-12
How to Cite
Aksenov, E. V., & Golovenko, V. B. (2016). The role of endothelial dysfunction in the formation of complications during interventional procedures. Ukrainian Journal of Cardiovascular Surgery, (2 (25), 101-104. Retrieved from https://cvs.org.ua/index.php/ujcvs/article/view/247
Section
GENERAL ISSUES of CARDIOVASCULAR SURGERY