Microbiological spectrum of pathogens in nosocomial forms of infective endocarditis
Abstract
Nosocomial infective endocarditis (IE) is an important public health problem and rates according to the literature 10–34% of all cases of IE. This disease is associated with nosocomial infection and accompanied by a high mortality rate when compared with community-acquired IE.
Objective. To study the influence of nosocomial factor on microbiological spectrum of infective endocarditis.
Materials and methods. Clinical data of 116 patients with infective endocarditis, who passed examination and treatment in SE “Amosov National Institute of Cardio-Vascular surgery of the Academy of Medical Sciences of Ukraine” from January 2014 to December 2016, were enrolled. Bacteriological blood tests were performed in all 116 patients with infective endocarditis.
Results. The incidence of nosocomial forms of infective endocarditis was 26.7% (31 case). In cases of hospital-acquired forms of IE Enterococcus spp was more prevalent – 13 (48.1%) cases, when compared with Staphylococcus spp. – 12 (18.5%) patients (p=0.018). The presence of Enterococcus spp. in blood cultures was associated with more frequent of registration of the mycelium of fungi in the intraoperative material – 12 (44%) patients (p=0.008). In cases of hospital-acquired IE fungal flora was identificated almost 2 times more often compared with community-acquired IE (p=0.019).
Conclusion. High frequency of simultaneous registration of enterococci combination with fungal flora points out to the need for timely administration of fungicidal drugs in patients with nosocomial forms of infective endocarditis.
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