Minimaly Invasive Interventions in Acute Tributary Varicothrombophlebitis of the Lower Extremities

  • Yaroslav M. Popovich Department of Surgical Diseases, Uzhhorod National University, Uzhhorod, Ukraine; Communal Nonprofit Enterprise “Central City Clinical Hospital” of Uzhhorod City Council, Uzhhorod, Ukraine https://orcid.org/0000-0002-8908-8541
  • Volodymyr S. Kostiunin Department of Surgical Diseases, Uzhhorod National University, Uzhhorod, Ukraine; Communal Nonprofit Enterprise “Central City Clinical Hospital” of Uzhhorod City Council, Uzhhorod, Ukraine https://orcid.org/0009-0006-5757-1826
Keywords: radiofrequency ablation, miniphlebectomy, phlebocentesis, sclerotherapy, cross-section, stripping

Abstract

Background. One of the formidable complications of varicose veins of the lower extremities is thrombophlebitis. The risk of developing venous thromboembolic complications remains high even when taking anticoagulants. Most authors do not even consider surgical elimination of the manifestations of acute superficial thrombophlebitis.

The aim. To evaluate the effectiveness of minimally invasive surgical treatment of acute tributary varicose veins of the lower extremities.

Materials and methods. The surgical treatment of 78 patients with acute varicothrombophlebitis of the tributaries of the great saphenous vein was analyzed. Depending on the treatment performed, patients were divided into two groups: group I including 56 (71.8%) patients who underwent inpatient surgery for thrombotic lesions of varicose veins of the tributaries of the great saphenous vein; group II including 22 (28.2%) patients who received conservative outpatient treatment.

Results. The choice of the volume of surgical intervention in patients of group I depended on the condition of thegreat saphenous vein. In the absence of thrombotic and varicose veins in 29 (51.8%) patients, the latter was preserved. With varicose changes in the great saphenous vein, 16 (28.6%) patients underwent radiofrequency ablation after ligationof the thrombosed tributary duct and miniphlebectomy or phlebocentesis with foam-form sclerotherapy. In 11 (19.6%) cases of thrombotic lesions of the great saphenous vein, crossectomy, long/short stripping or phlebocentesis with stem sclerotherapy after ligation of its tributaries and isolation of the latter distal to the thrombotic occlusion was performed. The surgical intervention was supplemented with miniphlebectomy of other varicose veins and ligation of failed perforator veins. In patients of group II, treatment was prescribed similarly to the treatment of deep vein thrombosis. Surgical treatment of patients in group I effectively prevented venous thromboembolic complications and reduced the manifestations of chronic venous insufficiency in 72.9% of cases.

Conclusions. Minimally invasive surgical intervention for acute thrombophlebitis of the tributaries of the great saphenous vein allows, on an outpatient basis or in a one-day hospital, to eliminate thrombotic lesions of varicose super-ficial veins and prevent venous thromboembolic complications, reduce or eliminate manifestations of chronic venous insufficiency, prevent recurrence of thrombosis, and reduce the patient’s disability.

References

  1. Décousus H, Bertoletti L, Frappé P, Becker F, Jaouhari AE, Mismetti P, et al. Recent findings in the epidemiology, diagnosis and treatment of superficial-vein thrombosis. Thromb Res. 2011;127 Suppl 3:S81-S85. https://doi.org/10.1016/S0049-3848(11)70022-6
  2. Leon L, Giannoukas AD, Dodd D, Chan P, Labropoulos N. Clinical Significance of Superficial Vein Thrombosis. Eur J Vasc Endovasc Surg. 2005;29(1):10-17. https://doi.org/10.1016/j.ejvs.2004.09.021
  3. Henni S, Ramondou P, Duval G, Picquet J, Leftheriotis G,Abraham P. The risk of lower-limb superficial vein thrombosis relative to lower-limb venous thrombotic events is not increased in winter months. Phlebology. 2020;35(7):533-537. https://doi.org/10.1177/0268355519896729
  4. Coon WW, Willis PW 3rd, Keller JB. Venous Thromboembolism and Other Venous Disease in the Tecumseh Community Health Study. Circulation. 1973;48(4):839-846. https://doi.org/10.1161/01.cir.48.4.839
  5. Decousus H, Prandoni P, Mismetti P, Bauersachs RM, Boda Z, Brenner B, et al.; CALISTO Study Group. Fondaparinux for the Treatment of Superficial-Vein Thrombosis in the Legs. N Engl J Med. 2010;363(13):1222-1232. https://doi.org/10.1056/NEJMoa0912072
  6. Galanaud JP, Genty C, Sevestre MA, Brisot D, Lausecker M, Gillet JL, et al.; OPTIMEV SFMV investigators. Predictive factors for concurrent deep-vein thrombosis and symptomatic venous thromboembolic recurrence in case of superficial venous thrombosis. The OPTIMEV study. Thromb Haemost. 2011;105(1):31-39. https://doi.org/10.1160/TH10-06-0406
  7. Beddar Chaib F, Jiménez Hernández S, Pedrajas Navas JM, Carriel Mancilla J, Castro Arias L, Merlo Loranca M, et al.; Grupo de Enfermedad Tromboembólica Venosa de la Sociedad Española de Medicina de Urgencias y Emergencias (ETV-SEMES). Characteristics of isolated superficial vein thrombosis and diagnostictherapeutic management in Spanish hospital emergency departments: the ALTAMIRA study. Emergencias. 2021;33(6):433-440.
  8. Sobreira ML, Maffei FH, Yoshida WB, Rollo HA, Lastória S, Griva BL, et al. Prevalence of deep vein thrombosis and pulmonary embolism in superficial thrombophlebitis of the lower limbs: prospective study of 60 cases. Int Angiol. 2009;28(5):400-408.
  9. Decousus H, Quéré I, Presles E, Becker F, Barrellier MT, Chanut M, et al.; POST (Prospective Observational Superficial Thrombophlebitis) Study Group. Superficial Venous Thrombosis and Venous Thromboembolism: A Large, Prospective Epidemiologic Study. Ann Intern Med. 2010;152(4):218-224. https://doi.org/10.7326/0003-4819-152-4-201002160-00006
  10. Quéré I, Leizorovicz A, Galanaud JP, Presles E, Barrellier MT, Becker F, et al.; Prospective Observational Superficial Thrombophlebitis (POST) Study Investigators. Superficial venous thrombosis and compression ultrasound imaging. J Vasc Surg. 2012;56(4):1032-1038.e1. https://doi.org/10.1016/j.jvs.2012.03.014
  11. Cosmi B, Filippini M, Campana F, Avruscio G, Ghirarduzzi A, Bucherini E, et al.; STEFLUX Investigators. Risk factorsfor recurrent events in subjects with superficial vein thrombosis in the randomized clinical trial SteFlux (Superficial Thromboembolism Fluxum). Thromb Res. 2014;133(2):196-202. https://doi.org/10.1016/j.thromres.2013.12.005
  12. Werth S, Bauersachs R, Gerlach H, Rabe E, Schellong S, Beyer-Westendorf J. Superficial vein thrombosis treated for 45 days with rivaroxaban versus fondaparinux: rationale and design of the SURPRISE trial. J Thromb Thrombolysis. 2016;42(2):197-204. https://doi.org/10.1007/s11239-016-1354-3
  13. Beyer-Westendorf J, Schellong SM, Gerlach H, Rabe E, Weitz JI, Jersemann K, et al.; SURPRISE investigators. Prevention of thromboembolic complications in patients with superficial-vein thrombosis given rivaroxaban or fondaparinux: the open-label, randomised, non-inferiority SURPRISE phase 3b trial. Lancet Haematol. 2017;4(3):e105-e113. https://doi.org/10.1016/S2352-3026(17)30014-5
  14. Frappé P, Buchmuller-Cordier A, Bertoletti L, Bonithon-Kopp C, Couzan S, Lafond P, et al.; STEPH Study Group. Annual diagnosis rate of superficial vein thrombosis of the lower limbs: the STEPH community-based study. J Thromb Haemost. 2014;12(6):831-838. https://doi.org/10.1111/jth.12575
  15. Décousus H, Bertoletti L, Frappé P. Spontaneous acute superficial vein thrombosis of the legs: do we really need to treat? J Thromb Haemost. 2015;13 Suppl 1:S230-S237. https://doi.org/10.1111/jth.12925
  16. Di Minno MN, Ambrosino P, Ambrosini F, Tremoli E, Di Minno G, Dentali F. Prevalence of deep vein thrombosis and pulmonary embolism in patients with superficial vein thrombosis: a systematic review and meta-analysis. J Thromb Haemost. 2016;14(5):964-972. https://doi.org/10.1111/jth.13279
  17. Popovich YaM, Boldizhar PO. Mini-invasive treatment of acute superficial varicothrombophlebitis of the lower extremities. Acta Phlebologica 2023;24(3):110-114. https://doi.org/10.23736/S1593-232X.23.00573-8
  18. Poredoš P, Spirkoska A, Ježovnik MK. In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate. ArchMed Sci. 2019;15(2):393-401. https://doi.org/10.5114/aoms.2019.83292
  19. Kitchens CS. How I treat superficial venous thrombosis. Blood. 2011;117(1):39-44. https://doi.org/10.1182/blood-2010-05-286690
  20. Di Nisio M, Wichers IM, Middeldorp S. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev. 2018;2(2):CD004982. https://doi.org/10.1002/14651858.cd004982.pub6
  21. Kemp MT, Obi AT, Henke PK, Wakefield TW. A narrative review on the epidemiology, prevention, and treatment of venous thromboembolic events in the context of chronic venous disease. J Vasc Surg Venous Lymphat Disord. 2021;9(6):1557-1567. https://doi.org/10.1016/j.jvsv.2021.03.018
  22. Cacione DG, Novaes FDC, Silva JCCB. Correlation between presence of lower limb varicose veins and deep venous thrombosis. J Vasc Bras. 2020;19:e20200081. https://doi.org/10.1590/1677-5449.200081
  23. Li R, Chen Z, Gui L, Wu Z, Miao Y, Gao Q, et al. Varicose Veins and Risk of Venous Thromboembolic Diseases: A Two-Sample-Based Mendelian Randomization Study. Front Cardiovasc Med. 2022;9:849027. https://doi.org/10.3389/fcvm.2022.849027
  24. Ortega MA, Fraile-Martínez O, García-Montero C, Álvarez-Mon MA, Chaowen C, Ruiz-Grande F, et al. Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management. J Clin Med. 2021;10(15):3239. https://doi.org/10.3390/jcm10153239
  25. Gracia S, Miserey G, Risse J, Abbadie F, Auvert JF, Chauzat B, et al. Update of the SFMV (French society of vascular medicine) guidelines on the conditions and safety measures necessary for thermal ablation of the saphenous veins and proposals for unresolved issues. J Med Vasc. 2020;45(3):130-146. https://doi.org/10.1016/j.jdmv.2020.03.005
  26. Tenezaca-Sari X, García-Reyes M, Escribano-Ferrer JM, Marrero C, Bellmunt-Montoya S. The CHIVA strategy applied to large-diameter saphenous veins. Int Angiol. 2022;41(4):332-337. https://doi.org/10.23736/S0392-9590.22.04831-3
Published
2024-06-27
How to Cite
1.
Popovich YM, Kostiunin VS. Minimaly Invasive Interventions in Acute Tributary Varicothrombophlebitis of the Lower Extremities. ujcvs [Internet]. 2024Jun.27 [cited 2024Dec.26];32(2):105-12. Available from: https://cvs.org.ua/index.php/ujcvs/article/view/654
Section
PATHOLOGY OF THE PERIPHERAL VASCULAR SYSTEM

Most read articles by the same author(s)