Dynamics in detection of markers of viral hepatitis B and C among blood donors and patients as an indicator of the quality of blood donor selection

  • A. O. Salamanina State Institution «Scientific and Practical Medical Centre for Children’s Cardiology and Cardiac Surgery of Ministry of Health of Ukraine» (Kyiv)
  • O. V. Yunatska State Institution «Scientific and Practical Medical Centre for Children’s Cardiology and Cardiac Surgery of Ministry of Health of Ukraine» (Kyiv)
  • I. A. Tretiakova State Institution «Scientific and Practical Medical Centre for Children’s Cardiology and Cardiac Surgery of Ministry of Health of Ukraine» (Kyiv)
Keywords: transfusion infection, hepatitis B, hepatitis C, blood transfusion, IHL-analysis, ELISA

Abstract

An important issue of the safety of donor’s blood is the spread of infections transmitted during blood transfusion, including viral hepatitis B and C. The results of testing donors and patients for markers of viral hepatitis B and C conducted at the UCCC’s Department of Transfusion Control during the period from 2013 until 2015 are presented. The research was done using IHL-analysis and ELISA. The material for the retrospective study was serum taken from 22,144 blood donors and patients, including 9090 samples taken from regular donors, 1,450 samples taken from individuals who wanted to become donors and 11,604 blood samples taken from patients. Tests of 23 samples (0.22%) of donors were found to be positive for HCV-antibodies, and tests of 6 samples (0.057%) were found to be positive for hepatitis B surface antigen. Identification of markers of hepatitis C among donors shows a stable downward trend. The frequency of detection of HBsAg in regular blood donors remains low, and the frequency of detection of HBsAg in individuals who want to become donors decreases.

References

1. Гепатит В. Информационный бюллетень ВОЗ. Март 2015 г.

2. Дзюблик І. В. Парентеральні вірусні гепатити. – Київ, 2005.

3. Долгов В. В. Клиническая лабораторная диагностика: национальное руководство; в 2т. – Т. II / В. В. Долгов, В. В. Меньшиков. – М. : ГЭОТАР–Медиа, 2012. – 808 с.

4. Вирусный гепатит С: современные возможности диагностики (клиническая лекция) / Дуда А. К., Бойко В. А. и др. // Актуальная инфектология. – 2015. – № 4 (9). – С. 9–16.

5. Кишкун А. А. Иммунологические и серологические исследования в клинической практике / А. А. Кишкун. – М. : ООО «Медицинское информационное агентство», 2006. – 356 с.

6. Осипов Д. М. Маркеры вирусных гепатитов В и С у доноров и трансфузионнозависимых больных: автореф. дисс. на соискание научной степени канд. мед. наук: спец. 14.00.29 «Гематология и переливание крови» / Д. М. Осипов. – Новосибирск, 2006. – 160 с.

7. Львов Д. К. Медицинская вирусология. – М. : Медицинское информационное агентство, 2008. – 656 с.

8. Рагимов А. А., Дашкова Н. Г. Основы трансфузионной иммунологии. – М. : Медицинское информационное агентство, 2004. – 280 с.

9. Ройт А. Иммунология / Перевод с английского; Ройт А., Бростофф Дж., Мейл Д. – М. : Мир, 2000. – 592 с.

10. Учайкин В. Ф. Руководство по инфекционным болезням / В. Ф. Учайкин. – М. : ГЭОТАР-Медиа, 2002. – 388 с.

11. Харченко Н. В., Порохницький В. Г., Топольницький В. С. Вірусні гепатити. – К. : Фенікс, 2002. – 296 с.

12. Цирроз печени при хроническом гепатите С у детей / Чуелов С. Б., Лейбман Е. А., Чередниченко Т. В. и др. // Детские инфекции. – 2013. – № 4. – С. 27–30.

13. R. Iorioetal. Chronic hepatitis C in childhood: an 18-year experience // Clin Infect Dis. – 2005. – 41. – P. 1431– 1434.

14. GlobalCommunityHepatitisPolicyReport2014 // World Hepatitis Alliance, 2014.

15. EASL Recommendations on Treatment of Hepatitis C 2015 // J. Hepatol. – 2015. – Vol. 63. – P. 199–236. at: http://www.easl.eu/medias/cpg/HEPC-2015/Full-report.pdf.

16. Lavanchy D. The global burden of hepatitis C // Liver International. – 2009. – Vol. 29, suppl. 1. – P. 74–81.

17. Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines Consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition / E. M. Soka, M. Paganelli, S. Wirth et al. // Journal of Hepatology. – 2013. – Vol. 59. – Р. 814–829.

18. Hepatitis C Among Blood Donors In ATeaching Hospital In North Central Nigeria / Nwannadi Ikenna Alexander, Alao Olusayo, Shoaga Lanre // IOSR Journal of Dentaland Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861. – Vol. 13, Issue 1 Ver. II (Jan. 2014). – P. 20–23.

19. Guidelines for the screening, care and treatment of persons with hepatitis C infection // WHO, April 2014.

20. Hepatitis C in the WHO European Region // Factsheet, July 2015.
Published
2018-11-30
How to Cite
Salamanina, A. O., Yunatska, O. V., & Tretiakova, I. A. (2018). Dynamics in detection of markers of viral hepatitis B and C among blood donors and patients as an indicator of the quality of blood donor selection. Ukrainian Journal of Cardiovascular Surgery, (4 (33), 77-81. https://doi.org/10.30702/ujcvs/18.33/19(077-081)
Section
GENERAL ISSUES of CARDIOVASCULAR SURGERY